Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin

The directed ortho metalation connection to aryl-aryl cross coupling.A general regiospecific synthesis of phenanthrols

J.‐M. FU, Matthew J. Sharp, Victor Snieckus · Tetrahedron Letters · 1988 · 83 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Synthesis and <i>N</i>‐Methyl‐<scp>D</scp>‐aspartate (NMDA) Antagonist Properties of the Enantiomers of α‐Amino‐5‐(phosphonomethyl)[1,1′‐biphenyl]‐3‐propanoic Acid. Use of a New Chiral Glycine Derivative

Werner Müller, David Lowe, H.C. Neijt et al. · Helvetica Chimica Acta · 1992 · 45 citations

Medicine, Chemistry, Pharmacology +13

Novel Natural Product 5,5-<i>trans</i>-Lactone Inhibitors of Human α-Thrombin:  Mechanism of Action and Structural Studies

Malcolm Weir, Susanne S. Bethell, Anne Cleasby et al. · Biochemistry · 1998 · 41 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

3-substituted-1,2,4-oxadiazolin-5-one; A useful amidine precursor and protecting group

R. Bolton, Steven J. Coote, Harry Finch et al. · Tetrahedron Letters · 1995 · 36 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7

5,5-Trans lactone-containing inhibitors of serine proteases: Identification of a novel, acylating thrombin inhibitor

Harry Finch, Neil Pegg, Jessica McLaren et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 17 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +11