Neil Pegg

Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

Luciano Nicosia, Gary J. Spencer, Nigel Brooks et al. · Cancer Cell · 2023 · 97 citations · Full text

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Brian S. Safina, Stewart Baker, Matt Baumgardner et al. · Journal of Medicinal Chemistry · 2012 · 66 citations · Full text

Drug Target, Immunology, Inflammatory Arthritis +25

[3.3] Sigmatropy within 1-vinyl-2-alkenyl-7,7-dimethyl-exo-norbornan-2-ols. The first atropselective oxyanionic Cope rearrangement

Leo A. Paquette, Neil Pegg, Dana S. Toops et al. · Journal of the American Chemical Society · 1990 · 60 citations

Cross-coupling Reaction, Molecular Sciences, Engineering +11

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Daniel P. Sutherlin, Stewart Baker, Angelina Bisconte et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 50 citations · Full text

Biochemistry, Functional Selectivity, Medicine +8

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors

Paul Beswick, Sharon Bingham, C. Bountra et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 46 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8