Concepedia

Association studies of CTLA-4 , CD28 , and ICOS gene polymorphisms with type 1 diabetes in the Japanese population

Kenji Ihara, Saifuddin Ahmed, Futoshi Nakao, Naoko Kinukawa, Ryuichi Kuromaru, Nobuo Matsuura, Isao Iwata, Seiho Nagafuchi, Hitoshi Kohno, Kenichi Miyako,

Immunogenetics · 2001 · 80 citations · 20 references

DOI

Concepts

References

20

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

, , +14

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Deborah J. Lenschow, Lesley Rhee, Neda Ashourian et al. · Immunity · 2000 · 2K citations · Full text

, , +16

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Andreas Hutloff, Anna‐Maria Dittrich, Katja C. Beier et al. · Nature · 1999 · 1.5K citations

, , +12

ICOS co-stimulatory receptor is essential for T-cell activation and function

Chen Dong, Amy E. Juedes, Ulla Angela Temann et al. · Nature · 2001 · 942 citations

, , +13

ICOS is essential for effective T-helper-cell responses

Arda Shahinian, Friedhelm Bladt, Steve K. Yoshinaga et al. · Nature · 2001 · 667 citations

, , +9