The Toxicity of the Alzheimer's β-Amyloid Peptide Correlates with a Distinct Fiber Morphology

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Estimation of globular protein secondary structure from circular dichroism

Stephen W. Provencher, Juergen Gloeckner · Biochemistry · 1981 · 2.2K citations

Life Sciences, Biochemistry, Protein Biochemistry +9

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury · Biochemistry · 1993 · 2K citations

Life Sciences, Biochemistry, Molecular Biology +17

Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass, Michael G. Schlossmacher, Albert Y. Hung et al. · Nature · 1992 · 1.9K citations

Life Sciences, Biochemistry, Cell Biology +15

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16