Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

Birgit Oppmann, Robin Lesley, Bianca Blom et al. · Immunity · 2000 · 2.8K citations · Full text

Life Sciences, Immunology, Cell Signaling +9

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

Hyun-Tak Jin, Ana C. Anderson, Wendy G. Tan et al. · Proceedings of the National Academy of Sciences · 2010 · 858 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

R. Brad Jones, Lishomwa C. Ndhlovu, Jason D. Barbour et al. · The Journal of Experimental Medicine · 2008 · 748 citations · Full text

Life Sciences, Immunology, Infectious Diseases +14

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

Hiroyuki Nishimura, Tasuku Honjo · Trends in Immunology · 2001 · 472 citations

Life Sciences, Immunology, Pathology +14

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

Marcin Kortylewski, Maciej Kujawski, Heehyoung Lee et al. · Cancer Cell · 2009 · 470 citations · Full text

Life Sciences, Immunology, Oncology +16