Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry · 1972 · 32.1K citations

Lipid Analysis, Hyperlipidemia, Direct Procedure +19

A simple salting out procedure for extracting DNA from human nucleated cells

S.A. Miller, Dale D. Dykes, Herbert F. Polesky · Nucleic Acids Research · 1988 · 20.4K citations · Full text

Chromatin, Dna Sequencing, Molecular Biological Method +11

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

Association of human aging with a functional variant of klotho

Dan E. Arking, Alice Krebsová, Milan Maçek et al. · Proceedings of the National Academy of Sciences · 2002 · 484 citations · Full text

Klotho Protein Protects against Endothelial Dysfunction

Yuichiro Saito, Takahiro Yamagishi, Yoshio Ohyama et al. · Biochemical and Biophysical Research Communications · 1998 · 279 citations

Inflammation, Atherosclerosis, Physiology +8