Substituted Imidazoles as Glucagon Receptor Antagonists

Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing.

Svetlana Mojsov, G. Heinrich, Ira B. Wilson et al. · Journal of Biological Chemistry · 1986 · 710 citations · Full text

Genetics, Glycobiology, Gastroenterology +20

Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*

Cathrine Ørskov, Jens J. Holst, Svend Knuhtsen et al. · Endocrinology · 1986 · 488 citations

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

Timothy F. Gallagher, George Seibel, Shouki Kassis et al. · Bioorganic & Medicinal Chemistry · 1997 · 218 citations

Inflammation, Cytokine, Reductive Stress +15

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

Immunology, Pharmacotherapy, Chemical Biology +17

Potent, orally absorbed glucagon receptor antagonists

Stephen E. de Laszlo, Candice Hacker, Bing Li et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 169 citations · Full text

G Protein-coupled Receptor, Medicine, Functional Selectivity +5