Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

References

Page 1

	Year	Citations
The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products Oyo Mitsunobu Synthesis EngineeringDiethyl AzodicarboxylateBiochemistryNatural SciencesActive Methylene Compounds	1981	4.1K
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain Harry F. Dovey, Varghese John, J. P. Anderson, Journal of Neurochemistry Protein SecretionNeurochemical BiomarkersAmyloid Precursor ProteinSocial SciencesAlzheimer's Disease	2001	877
The role of presenilin cofactors in the γ-secretase complex Nobumasa Takasugi, Taisuke Tomita, Ikuo Hayashi, Nature Protein SecretionProtein FunctionSignal TransductionBiochemistryNatural Sciences	2003	862
Synthesis of .alpha.,.beta.-unsaturated carbonyl compounds by palladium(II)-catalyzed dehydrosilylation of silyl enol ethers Yoshihiko Ito, Toshikazu Hirao, Takeo Saegusa The Journal of Organic Chemistry Derivative (Chemistry).Beta.-unsaturated Carbonyl CompoundsEngineeringDonut IconAltmetric Attention Score	1978	849
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet, Journal of Biological Chemistry	2004	715
Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation Joseph Milano, Jenny McKay, Claude Dagenais, Toxicological Sciences Genes KnownGastroenterologyPathologyPharmacotherapyExperimental Pharmacology	2004	557
Ns strategies: a highly versatile synthetic method for amines Toshiyuki Kan, Tohru Fukuyama Chemical Communications EngineeringNs StrategiesMedicineNs GroupTotal Synthesis	2004	505
Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor George H. Searfoss, William H. Jordan, David O. Calligaro, Journal of Biological Chemistry	2003	336
Total Synthesis of Ecteinascidin 743 Atsushi Endo, Arata Yanagisawa, Masanao Abe, Journal of the American Chemical Society	2002	285
Stereocontrolled Total Synthesis of (+)-Vinblastine Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Journal of the American Chemical Society Stereocontrolled Total SynthesisNovel Indole SynthesisDiversity-oriented SynthesisNatural SciencesTotal Synthesis	2002	238

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