The role of presenilin cofactors in the γ-secretase complex

Nobumasa Takasugi, Taisuke Tomita, Ikuo Hayashi, +5

Nature

Protein SecretionProtein FunctionSignal TransductionBiochemistryNatural Sciences +4

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

Nobumasa Takasugi, Tomoki Sasaki, K. Suzuki, +11

Journal of Neuroscience

Amyloid-β PeptideBace1 Activity IsSynaptic SignalingCellular PhysiologyNeuroinflammation +16

Molecular Cloning and Characterization of CALP/KChIP4, a Novel EF-hand Protein Interacting with Presenilin 2 and Voltage-gated Potassium Channel Subunit Kv4

Yuichi Morohashi, Noriyuki Hatano, Susumu Ohya, +6

Journal of Biological Chemistry

C Terminus of Presenilin Is Required for Overproduction of Amyloidogenic Aβ42 through Stabilization and Endoproteolysis of Presenilin

Taisuke Tomita, Rie Takikawa, Akihiko Koyama, +5

Journal of Neuroscience

Molecular BiologyAlzheimer's DiseasePresenilin Is RequiredProtein FoldingC Terminus +15

The First Proline of PALP Motif at the C Terminus of Presenilins Is Obligatory for Stabilization, Complex Formation, and γ-Secretase Activities of Presenilins

Taisuke Tomita, Tomonari Watabiki, Rie Takikawa, +5

Journal of Biological Chemistry

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

Nobumasa Takasugi, Tomoki Sasaki, Ihori Ebinuma, +5

PLoS ONE

S1pr ModulatorsNeurochemical BiomarkersSynaptic SignalingSocial SciencesNeuroinflammation +20

Aph-1 Contributes to the Stabilization and Trafficking of the γ-Secretase Complex through Mechanisms Involving Intermolecular and Intramolecular Interactions

Manabu Niimura, Noriko Isoo, Nobumasa Takasugi, +6

Journal of Biological Chemistry

Protein Secretionγ-Secretase ComplexMolecular BiologyCytoskeletonIntramolecular Interactions +16

Aβ42 Overproduction Associated with Structural Changes in the Catalytic Pore of γ-Secretase

Noriko Isoo, Chihiro Sato, Hiroyuki Miyashita, +6

Journal of Biological Chemistry

Protein SecretionMolecular BiologyCatalytic PoreAβ42 Overproduction AssociatedAlzheimer's Disease +15

Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity

Nobumasa Takasugi, Tomoki Sasaki, Mitsuru Shinohara, +2

Biochemical and Biophysical Research Communications

BiochemistryNatural SciencesAmyloid-β 42Neurochemical BiomarkersProtein Misfolding +4

The Mechanism of γ-Secretase Activities through High Molecular Weight Complex Formation of Presenilins Is Conserved inDrosophila melanogaster and Mammals

Nobumasa Takasugi, Yasuko Takahashi, Yuichi Morohashi, +2

Journal of Biological Chemistry