TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells

Disruption of epithelial cell-matrix interactions induces apoptosis

SM Frisch, H. Francis · The Journal of Cell Biology · 1994 · 3.2K citations · Full text

Anchorage Independence, Cell Regulation, Tumor Microenvironment +15

FLASH assembly of TALENs for high-throughput genome editing

Deepak Reyon, Shengdar Q. Tsai, Cyd Khayter et al. · Nature Biotechnology · 2012 · 1.2K citations · Full text

Engineering, Genome Surgery, Synthetic Biology +8

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis

Joseph Zabner, Larry A. Couture, Richard J. Gregory et al. · Cell · 1993 · 677 citations

Gene Therapies, Chloride Transport Defect, Adenovirus-mediated Gene Transfer +4

Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair

Thomas O. Auer, Karine Duroure, Anne De Cian et al. · Genome Research · 2013 · 646 citations · Full text

Chromatin, Off-target Effect, Crispr/cas9 System +14

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

Mitchell L. Drumm, Heidi A. Pope, William Cliff et al. · Cell · 1990 · 575 citations · Full text

In Vivo Gene Therapy, Retrovirus-mediated Gene Transfer, Reverse Genetics +11