Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

Zhenglong Yuan, Yingjie Guan, Devasis Chatterjee et al. · Science · 2005 · 765 citations

Stat3 Mutant, Wild-type Stat3, Signal Transducers +20

Chemical phylogenetics of histone deacetylases

James E. Bradner, Nathan West, Melissa L. Grachan et al. · Nature Chemical Biology · 2010 · 709 citations · Full text

Biology, Histone Modifications, Chromatin +8

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

Teru Hideshima, James E. Bradner, Jason Chun Yu Wong et al. · Proceedings of the National Academy of Sciences · 2005 · 595 citations · Full text

Hematological Malignancy, Tumor Biology, Ubiquitinated Proteins +15

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

Loredana Santo, Teru Hideshima, Andrew L. Kung et al. · Blood · 2012 · 594 citations · Full text

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Teru Hideshima, Laurence Catley, Hiroshi Yasui et al. · Blood · 2006 · 420 citations · Full text