Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

Zhenglong Yuan, Yingjie Guan, Devasis Chatterjee et al. · Science · 2005 · 777 citations

Life Sciences, Molecular Biology, Oncology +13

Chemical phylogenetics of histone deacetylases

James E. Bradner, Nathan West, Melissa L. Grachan et al. · Nature Chemical Biology · 2010 · 728 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

Loredana Santo, Teru Hideshima, Andrew L. Kung et al. · Blood · 2012 · 601 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

Teru Hideshima, James E. Bradner, Jason Chun Yu Wong et al. · Proceedings of the National Academy of Sciences · 2005 · 596 citations · Full text

Medicine, Oncology, Pharmacology +14

Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

Teru Hideshima, Laurence Catley, Hiroshi Yasui et al. · Blood · 2006 · 421 citations · Full text

Medicine, Oncology, Pharmacology +15