Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

Francesca Cottini, Teru Hideshima, Chunxiao Xu, +18

Nature Medicine

Risk factors for acute renal failure in trauma patients

Gabriella Vivino, Massimo Antonelli, Maria Luisa Moro, +5

Intensive Care Medicine

MedicineKidney FailureAcute Kidney InjuryChronic Kidney DiseaseRisk Factors +2

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

J. Minami, Rikio Suzuki, Ralph Mazitschek, +12

Leukemia

Histone ModificationsChromatinTumor BiologyHistone Deacetylase 3Oncology +9

General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL

Claudia Fazi, Lydia Scarfò, Lorenza Pecciarini, +9

Blood

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

Michele Cea, Antonia Cagnetta, Mariateresa Fulciniti, +15

Blood

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Teru Hideshima, Jun Qi, Ronald M. Paranal, +18

Proceedings of the National Academy of Sciences

Hematological MalignancyTumor BiologyProteasome Inhibitor ResistanceHdac6 InhibitionMedicine +12

Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma

Francesca Cottini, Teru Hideshima, Rikio Suzuki, +5

Cancer Discovery

Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma

Shohei Kikuchi, Rikio Suzuki, Hiroto Ohguchi, +10

Leukemia

Hematological MalignancyTumor BiologyMedicineApoptosisImmunology +6

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition

Naoya Mimura, Teru Hideshima, Toshiyasu Shimomura, +15

Cancer Research

ApoptosisImmunologyCell DeathImmunotherapyMyeloid Neoplasia +15

Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma

Teru Hideshima, Francesca Cottini, Hiroto Ohguchi, +6

Blood Cancer Journal