Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

Naoya Mimura, Mariateresa Fulciniti, Güllü Görgün, +22

Blood

Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma

Güllü Görgün, Elisabetta Calabrese, Ender Soydan, +14

Blood

Dilated Cardiomyopathy Caused by Aberrant Endoplasmic Reticulum Quality Control in Mutant KDEL Receptor Transgenic Mice

Hiromichi Hamada, Masashi Suzuki, Shigeki Yuasa, +8

Molecular and Cellular Biology

Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

J. Minami, Rikio Suzuki, Ralph Mazitschek, +12

Leukemia

Histone ModificationsChromatinTumor BiologyHistone Deacetylase 3Oncology +9

Immunohistochemical study of human advanced glycosylation end-products (AGE) in chronic renal failure.

Kenneth M. Yamada, Y Miyahara, K Hamaguchi, +7

PubMed

Renal PathologyGlycobiologyPathologyCapd TherapyGlycoproteomics +20

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

Teru Hideshima, Jun Qi, Ronald M. Paranal, +18

Proceedings of the National Academy of Sciences

Hematological MalignancyTumor BiologyProteasome Inhibitor ResistanceHdac6 InhibitionMedicine +12

The KDM3A–KLF2–IRF4 axis maintains myeloma cell survival

Hiroto Ohguchi, Teru Hideshima, Manoj Bhasin, +15

Nature Communications

Hematological MalignancyCancer ResearchKdm3a–klf2–irf4 AxisImmunologyCell Death +10

Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma

Claire Fabre, Naoya Mimura, Kathryn Bobb, +13

Clinical Cancer Research

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

Ola Rizq, Naoya Mimura, Motohiko Oshima, +12

Clinical Cancer Research

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition

Naoya Mimura, Teru Hideshima, Toshiyasu Shimomura, +15

Cancer Research

ApoptosisImmunologyCell DeathImmunotherapyMyeloid Neoplasia +15