A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz et al. · The Journal of Immunology · 2009 · 2.9K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Laetitia Agostini, Fabio Martinon, Kimberly Burns et al. · Immunity · 2004 · 1.7K citations · Full text

Life Sciences, Immunology, Pathology +15

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hal M. Hoffman, James L. Mueller, David H. Broide et al. · Nature Genetics · 2001 · 1.7K citations

Life Sciences, Genetics, Molecular Genetics +9

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

Helen J. Lachmann, Isabelle Koné‐Paut, Jasmin Kuemmerle‐Deschner et al. · New England Journal of Medicine · 2009 · 858 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +11

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

Martin Keller, Andreas Rüegg, Sabine Werner et al. · Cell · 2008 · 839 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11