Inhibitor Mediated Protein Degradation

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai et al. · Proceedings of the National Academy of Sciences · 2001 · 2.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

Rajesh K. Thimmulappa, Kim H., Sorachai Srisuma et al. · PubMed · 2002 · 1.2K citations

Life Sciences, Molecular Biology, Toxicology +17

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Lakshmi Raj, Takao Ide, Aditi U. Gurkar et al. · Nature · 2011 · 1K citations

Medicine, Cancer Biology, Oncology +15

A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules

Laura A. Banaszynski, Ling-chun Chen, Lystranne A. Maynard-Smith et al. · Cell · 2006 · 958 citations · Full text

Life Sciences, Biochemistry, Cell Biology +10

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

Byung‐Hoon Lee, Min Jae Lee, Soyeon Park et al. · Nature · 2010 · 932 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13