Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

Tadahiro Shimazu, Matthew D. Hirschey, John C. Newman et al. · Science · 2012 · 1.6K citations · Full text

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Geert J.P.L. Kops, Tobias B. Dansen, Paulien E. Polderman et al. · Nature · 2002 · 1.5K citations

Reductive Stress, Transcriptional Regulation, Systems Biology +8

Mammalian SIRT1 Represses Forkhead Transcription Factors

Maria Carla Motta, Nullin Divecha, Madeleine E. Lemieux et al. · Cell · 2004 · 1.3K citations · Full text

Transcriptional Regulation, Genetics, Gene Regulation +4

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

Jay L. Zweíer, John T. Flaherty, Myron L. Weisfeldt · Proceedings of the National Academy of Sciences · 1987 · 1.2K citations · Full text

Cardiac Muscle, Biomedical Engineering, Cardiovascular Function +20

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Nagalingam R. Sundaresan, Madhu Gupta, Gene Kim et al. · Journal of Clinical Investigation · 2009 · 982 citations · Full text