Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Marco Antonio Meraz‐Ríos, J. Michael White, Kathleen C. F. Sheehan, +12

Cell

Transcriptional RegulationSignal TransductionSignaling PathwayMolecular PathwayCell Regulation +7

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

Joan E. Durbin, Renée Hackenmiller, M. Celeste Simon, +1

Cell

IL-4 directs the development of Th2-like helper effectors.

Susan L. Swain, Andrew D. Weinberg, M English, +1

The Journal of Immunology

Lymphocyte DevelopmentImmunologyImmune RegulationTh2 SubsetsImmunologic Mechanism +15

Generation and Analysis of Interleukin-4 Deficient Mice

Ralf Kühn, Klaus Rajewsky, Werner Müller

Science

InflammationCytokineImmunogeneticsAutoimmune DiseaseAllergy +11

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

Manfred Köpf, Graham Le Gros, Martin F. Bachmann, +3

Nature

InflammationCytokineAutoimmune DiseaseT-regulatory CellImmunology +7

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Graham Le Gros, Shlomo Z. Ben‐Sasson, Robert A. Seder, +2

The Journal of Experimental Medicine

Adaptive Immune SystemImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +14

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

Jinzhao Hou, Ulrike Schindler, William J. Henzel, +3

Science

InflammationIl-4 ReceptorCytokineAllergyAutoimmune Disease +9

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

Robert L. Coffman, J Ohara, M W Bond, +3

The Journal of Immunology

Ige ResponseAdaptive Immune SystemHumoral ResponseImmunologyImmune Regulation +20

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

Jian-Xin Lin, Thi-Sau Migone, Monica Tseng, +8

Immunity

InflammationCommon Stat ProteinsCytokineSignal TransductionAutoimmune Disease +9

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

N.G. Jacobson, Susanne J. Szabo, R Weber-Nordt, +4

The Journal of Experimental Medicine

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismCd4 T Cell Responses +17