Type 2 Immunity is a host defense mechanism characterized by the activation of CD4+ T helper 2 cells, eosinophils, basophils, mast cells, and the production of cytokines such as IL-4, IL-5, and IL-13, which collectively mediate resistance to helminth infections and promote tissue repair and allergic inflammation.
906
Publications
88.4K
Citations
5.4K
Authors
1.4K
Institutions
Publications per year
2017–2026
241
Variants
Type 2 Immune Response
Parents
Publications
906
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills‐Karp, Jackie Luyimbazi, Xueying Xu et al. · Science · 1998 · 2.6K citations
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Daniel R. Neill, See Heng Wong, Agustin Bellosi et al. · Nature · 2010 · 2K citations · Full text
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
Kazuya Shimoda, Jan van Deursent, Mark Y. Sangster et al. · Nature · 1996 · 1.3K citations
Life Sciences, Genetics, Immunology +16
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
Mark H. Kaplan, Ya‐Lin Sun, Timothy Hoey et al. · Nature · 1996 · 1.2K citations
Life Sciences, Immunology, Pathology +16
1–5 of 906
Authors
5.4K
- ANAndrew N. J. McKenzie
MRC Laboratory of Molecular Biology, United Kingdom
32 publications · 8.6K citations
25
h-index
- JFJoseph F. Urban
Beltsville Human Nutrition Research Center, United States
21 publications · 3.1K citations
21
h-index
- PG
18
h-index
- RK
18
h-index
- RM
17
h-index
1–5 of 5.4K
Institutions
1.4K
National Institutes of Health
Bethesda, United States
41 h-index
200 publications
26K citations
National Institute of Allergy and Infectious Diseases
Bethesda, United States
41 h-index
205 publications
30.6K citations
University of Edinburgh
Edinburgh, United Kingdom
28 h-index
141 publications
21K citations
MRC Laboratory of Molecular Biology
Cambridge, United Kingdom
26 h-index
124 publications
43.2K citations
University of Manchester
Manchester, United Kingdom
26 h-index
96 publications
8.5K citations
Howard Hughes Medical Institute
Chevy Chase, United States
26 h-index
75 publications
18.9K citations
Harvard University
Cambridge, United States
25 h-index
104 publications
12K citations
University of Pennsylvania
Philadelphia, United States
25 h-index
144 publications
25.7K citations
1–8 of 1.4K
Venues
- The Journal of Immunology
JI · 148 publications · 15K citations
70
h-index
- The Journal of Experimental Medicine
38 publications · 10K citations
37
h-index
- Journal of Allergy and Clinical Immunology
30 publications · 3.4K citations
27
h-index
- European Journal of Immunology
EJI · 34 publications · 2K citations
24
h-index
- Proceedings of the National Academy of Sciences
PNAS · 23 publications · 3.6K citations
21
h-index
1–5