Concepedia

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

Matthew P. Patricelli, Tyzoon Nomanbhoy, Jiangyue Wu, Heidi E. Brown, David Zhou, Jianming Zhang, Subadhra Jagannathan, Arwin Aban, Eric Okerberg, Chris Herring,

Chemistry & Biology · 2011 · 357 citations · 34 references

DOI

Concepts

References

34

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

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A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

, , +13

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Ana Cuenda, J.B. Rouse, Yair N. Doza et al. · FEBS Letters · 1995 · 2.1K citations

, , +14

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations

, , +15