SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

Identification and Importance of Brown Adipose Tissue in Adult Humans

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

Histone Modifications, Chromatin, Transcriptional Regulation +12

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

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Obesity, Metabolic Syndrome, Energy Homeostasis +12

PRDM16 controls a brown fat/skeletal muscle switch

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Muscle Function, Signal Transduction, Molecular Physiology +3

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Frédéric Picard, Martin V. Kurtev, Namjin Chung et al. · Nature · 2004 · 1.9K citations · Full text

Fat Mobilization, Signal Transduction, Cell Signaling +7