SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

Giorgio Ramadori, Teppei Fujikawa, Makoto Fukuda, +9

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisMolecular NeuroscienceAppetite Control +11

Role of the Central Melanocortin Circuitry in Adaptive Thermogenesis of Brown Adipose Tissue

Adriana Voss-Andreae, Jonathan G. Murphy, Kate L. J. Ellacott, +4

Endocrinology

CytoskeletonOptogeneticsCellular PhysiologyCentral Melanocortin CircuitryGastrointestinal Peptide Hormone +20

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

Nicole E. Cyr, Mario Perelló, Bogdan Patedakis Litvinov, +3

Journal of Biological Chemistry

Impairs ProopiomelanocortinEr StressCaloric RestrictionAdipokinesInsulin Signaling +20

Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone

Vanesa C. Sanchez, Jorge Goldstein, Ronald C. Stuart, +5

Journal of Clinical Investigation

Deletion of the Nhlh2 Transcription Factor Decreases the Levels of the Anorexigenic Peptides α Melanocyte-Stimulating Hormone and Thyrotropin-Releasing Hormone and Implicates Prohormone Convertases I and II in Obesity

Enxuan Jing, Eduardo A. Nillni, Vanesa C. Sanchez, +2

Endocrinology

Nhlh2 Transcription FactorImmunologyAdipokinesObesityMetabolic Syndrome +23

Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level

Mario Perelló, Nicole E. Cyr, Amparo Romero, +4

American Journal of Physiology-Endocrinology and Metabolism

The Role of Intracerebroventricular Administration of Leptin in the Stimulation of Prothyrotropin Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus

Mario Perelló, Ronald C. Stuart, Eduardo A. Nillni

Endocrinology

N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin

Li Guo, Heike Münzberg, Ronald C. Stuart, +2

Proceedings of the National Academy of Sciences

Differential effects of fasting and leptin on proopiomelanocortin peptides in the arcuate nucleus and in the nucleus of the solitary tract

Mario Perelló, Ronald C. Stuart, Eduardo A. Nillni

American Journal of Physiology-Endocrinology and Metabolism

Solitary TractPomc BiosynthesisGastrointestinal Peptide HormonePomc MrnaNeuroendocrine Mechanism +19

Thyroid Hormones Selectively Regulate the Posttranslational Processing of Prothyrotropin-Releasing Hormone in the Paraventricular Nucleus of the Hypothalamus

Mario Perelló, Theodore C. Friedman, Verónica Páez-Espinosa, +3

Endocrinology

Parathyroid GlandParaventricular NucleusProthyrotropin-releasing HormonePituitary GlandNeuroendocrine Mechanism +19