Synthesis and anti-HIV activities of urea-pETT analogs belonging to a new class of potent non-nucleoside HIV-1 Reverse transcriptase inhibitors

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Rudi Pauwels, Koen Andries, Jan Desmyter et al. · Nature · 1990 · 757 citations

Medicine, Medicinal Chemistry, Pharmacology +12

New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

O. S. Weislow, Rebecca Kiser, Donald L. Fine et al. · JNCI Journal of the National Cancer Institute · 1989 · 691 citations

Public Health, Infectious Diseases, Hiv Control +7

Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs

Frank W. Bell, Amanda Cantrell, Marita Hoegberg et al. · Journal of Medicinal Chemistry · 1995 · 455 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones

Karl D. Hargrave, John Proudfoot, Karl Grozinger et al. · Journal of Medicinal Chemistry · 1991 · 208 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 2

Michael J. Kukla, Henry J. Breslin, Craig J. Diamond et al. · Journal of Medicinal Chemistry · 1991 · 166 citations

Pharmacy, Chemistry, Medicinal Chemistry +12