Publication | Open Access

KMI-008, a novel β-Secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-State mimic: design and synthesis of substrate-based octapeptides

BiosynthesisBiochemistryTransition-state MimicNatural SciencesBiocatalysisEnzyme CatalysisMolecular BiologyPeptide SynthesisSubstrate-based OctapeptidesPeptide ScienceNovel β-Secretase Inhibitor