Soko Kasai

Design and synthesis of highly active Alzheimer’s β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

Tooru Kimura, Daisuke Shuto, Y. Hamada et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 95 citations · Full text

Active Alzheimer ’, Medicinal Chemistry, Neurodegenerative Diseases +12

KMI-008, a novel β-Secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-State mimic: design and synthesis of substrate-based octapeptides

Daisuke Shuto, Soko Kasai, Tooru Kimura et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 78 citations · Full text

Biosynthesis, Biochemistry, Transition-state Mimic +8

Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin

Soko Kasai, Hideko Nagasawa, Mariko Shimamura et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 72 citations

Antiangiogenic/heparin-binding Arginine Dendrimer, Peptide Therapeutic, Pharmacology +2

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

Tooru Kimura, Daisuke Shuto, Soko Kasai et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 64 citations · Full text

Small-sized Bace1 Inhibitors, Biochemistry, Medicine +10

New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues

Soko Kasai, Hideko Nagasawa, Mao Yamashita et al. · Bioorganic & Medicinal Chemistry · 2001 · 43 citations

Medicinal Chemistry, Natural Sciences, Medicine +8