Design and synthesis of highly active Alzheimer’s β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

Tooru Kimura, Daisuke Shuto, Y. Hamada, +7

Bioorganic & Medicinal Chemistry Letters

Active Alzheimer ’Medicinal ChemistryNeurodegenerative DiseasesAlzheimer's DiseaseBiochemistry +10

KMI-008, a novel β-Secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-State mimic: design and synthesis of substrate-based octapeptides

Daisuke Shuto, Soko Kasai, Tooru Kimura, +9

Bioorganic & Medicinal Chemistry Letters

BiosynthesisBiochemistryTransition-state MimicNatural SciencesBiocatalysis +6

Design and synthesis of antiangiogenic/heparin-binding arginine dendrimer mimicking the surface of endostatin

Soko Kasai, Hideko Nagasawa, Mariko Shimamura, +2

Bioorganic & Medicinal Chemistry Letters

Antiangiogenic/heparin-binding Arginine DendrimerPeptide TherapeuticPharmacologyNovel TherapyBiomolecular Engineering

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

Tooru Kimura, Daisuke Shuto, Soko Kasai, +10

Bioorganic & Medicinal Chemistry Letters

Small-sized Bace1 InhibitorsBiochemistryMedicineNatural SciencesRational Drug Design +8

New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues

Soko Kasai, Hideko Nagasawa, Mao Yamashita, +8

Bioorganic & Medicinal Chemistry

Medicinal ChemistryNatural SciencesMedicineOrganic ChemistryBiological Activities +6

Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles

Hitoshi Hori, Chengzhe Jin, Masatoshi Kiyono, +3

Bioorganic & Medicinal Chemistry

Biological ActivityMedicinePharmacological AgentOrganic ChemistryPharmacotherapy +6

The first total synthesis of lymphostin

Kuniaki Tatsuta, Keisuke Imamura, Sayaka Itoh, +1

Tetrahedron Letters

BiosynthesisImmunologyFirst Total SynthesisLymphatic SystemLymphatic Disease +3

Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic

Hikoichiro Maegawa, Tooru Kimura, Yasuhiro Arii, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryTransition-state MimicNatural SciencesPeptoid +7

The First Total Synthesis of Vinaxanthone, a Fungus Metabolite Possessing Multiple Bioactivities

Kuniaki Tatsuta, Soko Kasai, Yuki Amano, +3

Chemistry Letters

Industrial MycologyBiosynthesisEngineeringBiochemistryMedicine +12

Change in oxygenation status in intratumour total and quiescent cells following gamma-ray irradiation, tirapazamine administration, cisplatin injection and bleomycin treatment.

Shin‐ichiro Masunaga, Ono K, Hitoshi Hori, +6

British Journal of Radiology

Radiation ExposurePathologyRadiation BiologyGamma-ray IrradiationTumor Biology +17