Takashi Hamada

Titanium Alkoxide-Based Method for Stereoselective Synthesis of Functionalized Conjugated Dienes

Takashi Hamada, Daisuke Suzuki, Hirokazu Urabe et al. · Journal of the American Chemical Society · 1999 · 98 citations

Natural Sciences, Chemistry, Organic Chemistry +13

Design and synthesis of highly active Alzheimer’s β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

Tooru Kimura, Daisuke Shuto, Y. Hamada et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

KMI-008, a novel β-Secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-State mimic: design and synthesis of substrate-based octapeptides

Daisuke Shuto, Soko Kasai, Tooru Kimura et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 78 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +14

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine

Tooru Kimura, Daisuke Shuto, Soko Kasai et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +5

Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors

Magne O. Sydnes, Yoshio Hayashi, Vinay K. Sharma et al. · Tetrahedron · 2006 · 57 citations

Pharmacy, Biochemistry, Medicinal Chemistry +13