Concepedia

Transition State Specificity

Transition State Specificity is a biochemical principle defining the preferential stabilization of the transition state of a substrate by an enzyme, distinguishing it from other substrate-related states through selective binding affinity that enhances catalytic efficiency.

69

Publications

3.7K

Citations

252

Authors

84

Institutions

Publications per year

2017–2026

7

Parents

Publications

69

The Energetic Basis of Specificity in the Eco RI Endonuclease—DNA Interaction

David Lesser, Michael R. Kurpiewski, Linda Jen‐Jacobson · Science · 1990 · 328 citations

, , +17

On earlier states of the biochemical system

Martynas Yčas · Journal of Theoretical Biology · 1974 · 226 citations

, , +8

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

M. D. Madhusudan, P. Akamine, Nguyen‐Huu Xuong et al. · Nature Structural Biology · 2002 · 207 citations

, , +16

A conserved superlocus regulates above- and belowground root initiation

Moutasem Omary, Naama Gil-Yarom, Chen Yahav et al. · Science · 2022 · 173 citations

, , +17

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

Jemy A. Gutierrez, Tamara Crowder, Agnes Rinaldo-Matthis et al. · Nature Chemical Biology · 2009 · 163 citations · Full text

, , +10

1–5 of 69

Authors

252

  1. RW
    Richard Wolfenden

    University of North Carolina at Chapel Hill, United States

    6 publications · 396 citations

    6

    h-index

  2. VL
    Vern L. Schramm

    Albert Einstein College of Medicine, United States

    4 publications · 383 citations

    4

    h-index

  3. DH
    Daniel Herschlag

    Stanford University, United States

    3 publications · 138 citations

    3

    h-index

  4. YK
    Yoshiaki Kiso

    Kyoto Pharmaceutical University, Japan

    3 publications · 234 citations

    3

    h-index

  5. AE
    Alan E. Senior

    University of Rochester Medical Center, United States

    3 publications · 183 citations

    3

    h-index

1–5 of 252

Institutions

84

  1. Albert Einstein College of Medicine

    Bronx, United States

    7 h-index

    23 publications

    1.9K citations

  2. Yeshiva University

    New York, United States

    5 h-index

    15 publications

    882 citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    4 h-index

    7 publications

    370 citations

  4. Institute of Molecular Biology and Biophysics

    Novosibirsk, Russia

    3 h-index

    3 publications

    234 citations

  5. Kyoto Pharmaceutical University

    Kyoto, Japan

    3 h-index

    11 publications

    858 citations

  6. University of Rochester Medical Center

    Rochester, United States

    3 h-index

    10 publications

    642 citations

  7. Stanford University

    Stanford, United States

    3 h-index

    7 publications

    302 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    10 publications

    442 citations

1–8 of 84

Venues

  1. Biochemistry

    15 publications · 813 citations

    15

    h-index

  2. Journal of the American Chemical Society

    JACS · 8 publications · 221 citations

    8

    h-index

  3. Journal of Biological Chemistry

    JBC · 7 publications · 443 citations

    7

    h-index

  4. Journal of Theoretical Biology

    4 publications · 275 citations

    4

    h-index

  5. Science

    3 publications · 552 citations

    3

    h-index

1–5