Jemy A. Gutierrez

Transition state analogs of 5′-methylthioadenosine nucleosidase disrupt quorum sensing

Jemy A. Gutierrez, Tamara Crowder, Agnes Rinaldo-Matthis et al. · Nature Chemical Biology · 2009 · 161 citations · Full text

Transition State Analogs, Natural Sciences, Molecular Biology +3

Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

Jemy A. Gutierrez, Wei Liu, Sylvie Perez et al. · Molecular Metabolism · 2021 · 80 citations · Full text

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Kentaro Futatsugi, Aaron Smith, Meihua Tu et al. · Journal of Medicinal Chemistry · 2020 · 69 citations · Full text

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

María B. Cassera, Keith Z. Hazleton, Emilio Merino et al. · PLoS ONE · 2011 · 68 citations · Full text

Antiparasitic Agent, Malaria, Molecular Biology +16

Picomolar Inhibitors as Transition-State Probes of 5′-Methylthioadenosine Nucleosidases

Jemy A. Gutierrez, Minkui Luo, Vipender Singh et al. · ACS Chemical Biology · 2007 · 65 citations · Full text