Individual and Combined Effects of Selective Cyclooxygenase‐2 Inhibitor and Omega‐3 Fatty Acid on Endotoxin‐Induced Periodontitis in Rats

Abstract

The results of the present study indicate that celecoxib and omega-3 fatty acid, when used individually, show a rather partial effect on the control of the analyzed mediators, but when combined they show a synergic effect and provide significant reductions in the gingival tissue levels of PGE2, PGF2alpha, LTB4, and PAF in LPS-induced experimental periodontitis. These findings may pioneer further clinical human studies investigating the possible place of celecoxib and omega-3 fatty acid in periodontal treatment.