COX-2 inhibitors

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Dean A. Kujubu, Bradley S. Fletcher, Brian Varnum et al. · Journal of Biological Chemistry · 1991 · 1.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

Daniel Picot, Patrick J. Loll, R. Michael Garavito · Nature · 1994 · 1.3K citations

Life Sciences, Biochemistry, Molecular Biology +11

Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

Fred E. Silverstein · Annals of Internal Medicine · 1995 · 1.1K citations

Medicine, Internal Medicine, Pharmacotherapy +16

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

Jianmin Fu, Jaime L. Masferrer, Karen Seibert et al. · Journal of Biological Chemistry · 1990 · 943 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13