Protection of Porcine Islet Xenografts in Mice Using Sertoli Cells and Monoclonal Antibodies

Abstract

These results show that transient administration of anti-LFA-1 mAb or anti-CD154 mAb is efficacious in prolonging NPI xenograft survival when islets are cotransplanted with SC. Interleukin-4 and Serpina3n may be important mediators of protection observed in this model.