Benzylidene ketal derivatives as M2 muscarinic receptor antagonists

Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data.

William Billard, Herbert Binch, Gordon Crosby et al. · Journal of Pharmacology and Experimental Therapeutics · 1995 · 102 citations

Medicine, Neurobiology, Pharmacology +17

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 98 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

π-Facial Diastereoselection in the 1,2-Addition of Allylmetal Reagents to 2-Methoxycyclohexanone and Tetrahydrofuranspiro-(2-cyclohexanone)

Leo A. Paquette, Paul C. Lobben · Journal of the American Chemical Society · 1996 · 73 citations

Natural Sciences, Chemistry, Catalysis +7

Cholinergic improvement of a naturally-occurring memory deficit in the young rat

Richard D. Smith, Michael K. Kistler, Mary Cohen-Williams et al. · Brain Research · 1996 · 46 citations

Life Sciences, Neurobiology, Neuroscience +16

SCH 57790: A novel M2 receptor selective antagonist

Jean E. Lachowicz, Derek Lowe, Ruth A. Duffy et al. · Life Sciences · 1999 · 29 citations

Medicine, Pharmacology, Pharmacotherapy +11