Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data.

William Billard, Herbert Binch, Gordon Crosby, +1

Journal of Pharmacology and Experimental Therapeutics

Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists

Yuguang Wang, Samuel Chackalamannil, Zhiyong Hu, +9

Bioorganic & Medicinal Chemistry Letters

Piperidinyl Piperidine AnaloguesFunctional SelectivityMedicineMechanism Of ActionPharmacological Agent +3

SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals

Galen Carey, William Billard, Herbert Binch, +10

European Journal of Pharmacology

Molecular PharmacologyLaboratory AnimalsMedicineNeurotransmitterNeuropharmacology +6

Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788

Jean E. Lachowicz, Ruth A. Duffy, Vilma Ruperto, +9

Life Sciences

NeuropsychologyNeurophysiologyMedicineNeurotransmitterAcetylcholine Release +10

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity

John W. Clader, William Billard, Herbert Binch, +12

Bioorganic & Medicinal Chemistry

Drug TargetBiochemistryMedicineAnthranilamide DerivativesMechanism Of Action +7

Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands

Joseph A. Kozlowski, Guowei Zhou, Jayaram R. Tagat, +10

Bioorganic & Medicinal Chemistry Letters

PharmacologyChemistryHeterocycle Chemistry

Diphenylsulfone muscarinic antagonists: piperidine derivatives with high m2 selectivity and improved potency

William Billard, Herbert Binch, Kristen Bratzler, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceMedicineDiphenylsulfone Muscarinic Antagonists +8

Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor

Joseph A. Kozlowski, Derek Lowe, Henry Guzik, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryFunctional SelectivityMedicineDiphenyl Sulfoxides +6

Benzylidene ketal derivatives as M2 muscarinic receptor antagonists

Craig D. Boyle, Samuel Chackalamannil, Lian-Yong Chen, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicineMechanism Of ActionPharmacological AgentNeuropharmacology +5

Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Craig D. Boyle, Samuel Chackalamannil, John W. Clader, +19

Bioorganic & Medicinal Chemistry Letters

Halonaphthoic Acid SubstitutionBiochemistryFunctional SelectivityMedicinePhysiology +6