Mcl-1 downregulation by YM155 contributes to its synergistic anti-tumor activities with ABT-263

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

Medicine, Molecular Biology, Oncology +14

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Christin Tse, Alexander R. Shoemaker, Jessica Adickes et al. · Cancer Research · 2008 · 2K citations · Full text

Medicine, Oncology, Pharmacology +16

YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts

Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama et al. · Cancer Research · 2007 · 506 citations

Medicine, Oncology, Pharmacology +17

Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

Sangkil Nam, Ralf Buettner, James Turkson et al. · Proceedings of the National Academy of Sciences · 2005 · 294 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Multicenter Phase II Trial of YM155, a Small-Molecule Suppressor of Survivin, in Patients With Advanced, Refractory, Non–Small-Cell Lung Cancer

Giuseppe Giaccone, Petr Zatloukal, Jaromı́r Roubec et al. · Journal of Clinical Oncology · 2009 · 245 citations

Medicine, Oncology, Pharmacology +15