ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

Christin Tse, Alexander R. Shoemaker, Jessica Adickes, +15

Cancer Research

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

Christin Tse, Takashi Sera, Alan P. Wolffe, +1

Molecular and Cellular Biology

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

H Zhang, J Chen, Sajid Khan Tahir, +24

Cell Death and Disease

Bcl-2 family proteins are essential for platelet survival

H Zhang, Paul Nimmer, Stephen K Tahir, +13

Cell Death and Differentiation

ThrombopoiesisThrombosisBlood PlateletImmunologyHematology +6

Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737

Stephen K. Tahir, Xiufen Yang, Mark G. Anderson, +9

Cancer Research

Sclc CellsMedicineOncogenic AgentImmunologyCancer Cell Biology +12

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

Cheol‐Min Park, Milan Bruncko, Jessica Adickes, +16

Journal of Medicinal Chemistry

Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models

Alex R. Shoemaker, Michael J. Mitten, Jessica Adickes, +15

Clinical Cancer Research

Hybrid Trypsinized Nucleosomal Arrays:  Identification of Multiple Functional Roles of the H2A/H2B and H3/H4 N-Termini in Chromatin Fiber Compaction

Christin Tse, Jeffrey C. Hansen

Biochemistry

Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line.

Christin Tse, Ruinua H Xiang, Todd Bracht, +1

PubMed

Cancer BiologyAdenocarcinoma Cell LineTumor BiologyShort ArmChromosome 3P21.3 +16

Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice.

RuiHua Xiang, Albert R. Davalos, Charles H. Hensel, +3

PubMed

Tumor BiologyOncologySuppresses Tumor FormationOncogenic AgentMedicine +12