YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts

Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama, +8

Cancer Research

UrologyInduces RegressionChemoprevention StrategyMedicineHormone-refractory Prostate Cancer +12

Broad spectrum and potent antitumor activities of YM155, a novel small‐molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models

Takahito Nakahara, Aya Kita, Kentaro Yamanaka, +8

Cancer Science

Chemoprevention StrategyXenograft ModelsPharmacotherapyTumor BiologyMolecular Pharmacology +19

Radiosensitizing Effect of YM155, a Novel Small-Molecule Survivin Suppressant, in Non–Small Cell Lung Cancer Cell Lines

Tsutomu Iwasa, Isamu Okamoto, Minoru Suzuki, +7

Clinical Cancer Research

Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models

Kentaro Yamanaka, Takahito Nakahara, Tomohiro Yamauchi, +5

Clinical Cancer Research

Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter.

Qiuying Cheng, Xiang Ling, Andrew Haller, +7

PubMed

GeneticsMolecular BiologyCancer BiologyTumor BiologySp1 Interaction +16

Sepantronium Bromide (YM155) induces disruption of the ILF3/p54nrb complex, which is required for survivin expression

Tomohiro Yamauchi, Naoto Nakamura, Masashi Hiramoto, +17

Biochemical and Biophysical Research Communications

Signal TransductionImmunologyMolecular BiologySurvivin ExpressionIlf3/p54nrb Complex +4

Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin

Naoto Nakamura, Tomohiro Yamauchi, Masashi Hiramoto, +14

Molecular & Cellular Proteomics

InflammationCancer ResearchTranscriptional RegulationCytokineSignaling Pathway +11

Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs

Tsutomu Iwasa, Isamu Okamoto, Ken Takezawa, +10

British Journal of Cancer

YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft model

Takahito Nakahara, Kentaro Yamanaka, Shinji Hatakeyama, +8

Anti-Cancer Drugs

Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphoma

Aya Kita, Takahito Nakahara, Kentaro Yamanaka, +7

Leukemia Research

OncologyMedicinePathologyAntitumor EffectsPharmacotherapy +6