Takahito Nakahara

YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts

Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama et al. · Cancer Research · 2007 · 502 citations

Urology, Induces Regression, Chemoprevention Strategy +14

Broad spectrum and potent antitumor activities of YM155, a novel small‐molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models

Takahito Nakahara, Aya Kita, Kentaro Yamanaka et al. · Cancer Science · 2010 · 165 citations

Chemoprevention Strategy, Xenograft Models, Pharmacotherapy +21

Radiosensitizing Effect of YM155, a Novel Small-Molecule Survivin Suppressant, in Non–Small Cell Lung Cancer Cell Lines

Tsutomu Iwasa, Isamu Okamoto, Minoru Suzuki et al. · Clinical Cancer Research · 2008 · 152 citations

Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models

Kentaro Yamanaka, Takahito Nakahara, Tomohiro Yamauchi et al. · Clinical Cancer Research · 2011 · 110 citations

Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter.

Qiuying Cheng, Xiang Ling, Andrew Haller et al. · PubMed · 2012 · 93 citations · Full text

Genetics, Molecular Biology, Cancer Biology +18