Two mechanisms underlying the loss of p16Ink4a function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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A DNA damage checkpoint response in telomere-initiated senescence

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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Restoration of p53 function leads to tumour regression in vivo

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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

Lynda Chin, Steven E. Artandi, Qiong Shen et al. · Cell · 1999 · 974 citations · Full text

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