Concepedia

Oligoproline Effects on Polyglutamine Conformation and Aggregation

Ashwani Kumar Thakur, Veronique M. Chellgren, Geetha Thiagarajan, Angela D. Williams, Brian W. Chellgren, Trevor P. Creamer, Ronald Wetzel

Journal of Molecular Biology · 2005 · 271 citations · 40 references

DOI

Concepts

References

40

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Marian DiFiglia, Ellen Sapp, Kathryn Chase et al. · Science · 1997 · 2.9K citations

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Montserrat Arrasate, Siddhartha Mitra, Erik S. Schweitzer et al. · Nature · 2004 · 2K citations

, , +15

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

Eberhard Scherzinger, Rudi Lurz, Mark Turmaine et al. · Cell · 1997 · 1.3K citations · Full text

, , +10

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

John M. Warrick, Ho Yin Edwin Chan, Gladys L. Gray-Board et al. · Nature Genetics · 1999 · 833 citations

, , +14

Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation

Jane S. Richardson, David Richardson · Proceedings of the National Academy of Sciences · 2002 · 773 citations · Full text

, , +15