Concepedia

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

Paolo Manzanillo, Janelle S. Ayres, Robert O. Watson, Angela C. Collins, G. H. B. Souza, Chris S. Rae, David S. Schneider, Ken Nakamura, Michael U. Shiloh, Jeffery S. Cox

Nature · 2013 · 576 citations · 33 references

DOI

Concepts

References

33

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

, , +10

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

, , +17

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Kiichi Nakahira, Jeffrey A. Haspel, Vijay Rathinam et al. · Nature Immunology · 2010 · 3K citations · Full text

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler, Kira M. Holmström, Diana Skujat et al. · Nature Cell Biology · 2010 · 2.8K citations

, , +12