A Novel Nonribose Agonist, LUF5834, Engages Residues That Are Distinct from Those of Adenosine-Like Ligands to Activate the Adenosine A2a Receptor

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonist

Veli‐Pekka Jaakola, Mark T. Griffith, Michael A. Hanson et al. · Science · 2008 · 1.8K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

Søren G. F. Rasmussen, Hee‐Jung Choi, Juan José Fung et al. · Nature · 2011 · 1.7K citations · Full text

Natural Sciences, Biochemistry, Biophysics +6

Operational models of pharmacological agonism

J.W. Black, P. Leff · Proceedings of the Royal Society of London. Series B, Biological sciences · 1983 · 1.1K citations

Medicine, Pharmacology, General Pharmacology +16

Crystal structure of opsin in its G-protein-interacting conformation

Patrick Scheerer, Jung Hee Park, Peter W. Hildebrand et al. · Nature · 2008 · 1K citations

Life Sciences, Biochemistry, Biophysics +14