Concepedia

Partial Agonist Interactions

Partial Agonist Interactions is a pharmacodynamic interaction characterized by the concurrent administration of a partial agonist and another agent at the same receptor site, wherein the partial agonist produces a submaximal response relative to a full agonist and can act as either an agonist or antagonist depending on the presence and concentration of the full agonist.

256

Publications

19.2K

Citations

1.3K

Authors

405

Institutions

Publications per year

2017–2026

25

Parents

Publications

256

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

Marek W. Radomski, Richard Palmer, Salvador Moncada · Proceedings of the National Academy of Sciences · 1990 · 1.1K citations

, , +14

Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

A.C.W. Pike · The EMBO Journal · 1999 · 971 citations · Full text

, , +17

Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors

Kevin D. Burris, Thaddeus F. Molski, Cen Xu et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 922 citations

, , +16

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

Tomas Barkhem, Bo Carlsson, Yvonne Nilsson et al. · Molecular Pharmacology · 1998 · 775 citations

, , +17

The structural basis for agonist and partial agonist action on a β1-adrenergic receptor

Tony Warne, R. Moukhametzianov, Jillian G. Baker et al. · Nature · 2011 · 622 citations · Full text

, , +16

1–5 of 256

Authors

1.3K

  1. EF
    Elinore F. McCance‐Katz

    Yale University, United States

    5 publications · 280 citations

    5

    h-index

  2. GD
    Gene D. Morse

    University at Buffalo, State University of New York, United States

    4 publications · 212 citations

    4

    h-index

  3. DE
    David E. Moody

    University of Utah, United States

    4 publications · 212 citations

    4

    h-index

  4. PM
    Petrie M. Rainey

    Yale University, United States

    4 publications · 212 citations

    4

    h-index

  5. DR
    D. Regoli

    Université de Sherbrooke, Canada

    4 publications · 93 citations

    4

    h-index

1–5 of 1.3K

Institutions

405

  1. National Institutes of Health

    Bethesda, United States

    12 h-index

    60 publications

    3.9K citations

  2. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    6 h-index

    36 publications

    1.9K citations

  3. University of Washington

    Seattle, United States

    6 h-index

    9 publications

    369 citations

  4. King's College London

    London, United Kingdom

    6 h-index

    14 publications

    1.1K citations

  5. Harvard University

    Cambridge, United States

    5 h-index

    18 publications

    1.6K citations

  6. University College London

    London, United Kingdom

    5 h-index

    8 publications

    580 citations

  7. University of Copenhagen

    Copenhagen, Denmark

    5 h-index

    27 publications

    1.4K citations

  8. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    5 h-index

    29 publications

    2K citations

1–8 of 405

Venues

  1. Journal of Medicinal Chemistry

    14 publications · 897 citations

    14

    h-index

  2. 13

    h-index

  3. European Journal of Pharmacology

    EJP · 13 publications · 1.1K citations

    12

    h-index

  4. Molecular Pharmacology

    12 publications · 1.4K citations

    12

    h-index

  5. Journal of Biological Chemistry

    JBC · 11 publications · 662 citations

    11

    h-index

1–5