T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

E O’Brien, Nely Wigler, Moshe Inbar et al. · Annals of Oncology · 2004 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +17

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

Yongjun Liu, Jun Zhang, Peter J. L. Lane et al. · European Journal of Immunology · 1991 · 746 citations

Life Sciences, Immunology, Pathology +17

Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes

E.T.M. Dams, Peter Laverman, Wim J.G. Oyen et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 587 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

Tatsuhiro Ishida, Masako Ichihara, Xinyu Wang et al. · Journal of Controlled Release · 2006 · 552 citations

Pharmacy, Immunology, Pharmacokinetics +11

Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times

D. D. Lasic, Francisco J. Plaza Martín, Alberto Gabizón et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1991 · 544 citations

Natural Sciences, Biochemistry, Biophysics +14