Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes

Tatsuhiro Ishida, Masako Ichihara, Xinyu Wang, +4

Journal of Controlled Release

Lipid PreparationPeg-specific IgmMedicineImmunologyExperimental Therapeutic +4

Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: Effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes

Tatsuhiro Ishida, Masae Harada, Xinyu Wang, +3

Journal of Controlled Release

Lipid PreparationChain LengthLipid DoseMedicineDrug Delivery Systems +5

Accelerated clearance of PEGylated liposomes in rats after repeated injections

Tatsuhiro Ishida, Ryuhei Maeda, Masako Ichihara, +2

Journal of Controlled Release

Lipid PreparationMedicineDrug Delivery SystemsBiomedical EngineeringLipid Movement +2

Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes

Tatsuhiro Ishida, Masako Ichihara, Xinyu Wang, +1

Journal of Controlled Release

Accelerated Blood ClearanceImportant RoleImmunologyHematologyLymphatic System +8

Accelerated clearance of a second injection of PEGylated liposomes in mice

Tatsuhiro Ishida, Kaori Masuda, Takako Ichikawa, +3

International Journal of Pharmaceutics

Lipid PreparationSecond InjectionMedicineLipid MovementPegylated Liposomes +3

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

Masako Ichihara, Taro Shimizu, Ami Imoto, +4

Pharmaceutics

ImmunologyImmune RegulationImmunologic MechanismExtracellular MicrovesiclesImmunotherapy +14

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs

Takuya Suzuki, Masako Ichihara, Kenji Hyodo, +5

International Journal of Pharmaceutics

Lipid PreparationMedicineImmunologyHematologyVeterinary Science +3

Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice

Tatsuhiro Ishida, Takako Ichikawa, Masako Ichihara, +2

Journal of Controlled Release

NanomedicineBiochemistryMedicineDrug Delivery SystemsLipid Movement +4

Intravenous Administration of Polyethylene Glycol-Coated (PEGylated) Proteins and PEGylated Adenovirus Elicits an Anti-PEG Immunoglobulin M Response

Taro Shimizu, Masako Ichihara, Yasuo Yoshioka, +3

Biological and Pharmaceutical Bulletin

Pegylated Adenovirus ElicitsImmunocytochemical TechniqueIntravenous AdministrationImmunologyImmunotherapy +15

Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats

Xinyu Wang, Tatsuhiro Ishida, Masako Ichihara, +1

Journal of Controlled Release

Health SciencesMedicinePhysiologyHematologyVascular Biology +5