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Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Bernard Barlaam, Sabina Cosulich, Sébastien L. Degorce, Martina Fitzek, Fabrizio Giordanetto, Stephen Green, Tord Inghardt, Laurent Hennequin, Urs J. Hancox, Christine Lambert‐van der Brempt,

Bioorganic & Medicinal Chemistry Letters · 2014 · 19 citations · 16 references

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16

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

, , +14

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

Shidong Jia, Zhenning Liu, Sen Zhang et al. · Nature · 2008 · 684 citations · Full text

, , +16

PI 3-kinase p110β: a new target for antithrombotic therapy

Shaun P. Jackson, Simone M. Schoenwaelder, Isaac Goncalves et al. · Nature Medicine · 2005 · 589 citations

, , +15

PTEN-deficient cancers depend on PIK3CB

Susan Wee, Dmitri Wiederschain, Sauveur-Michel Maira et al. · Proceedings of the National Academy of Sciences · 2008 · 552 citations · Full text

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PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control

Maria‐Magdalena Georgescu · Genes & Cancer · 2010 · 478 citations · Full text

, , +17