Highly diastereoselective reaction of a chiral, non-racemic amide enolate with (S)-glycidyl tosylate. Synthesis of the orally active HIV-1 protease inhibitor L-735,524

Equilibrium acidities in dimethyl sulfoxide solution

F. G. Bordwell · Accounts of Chemical Research · 1988 · 2.8K citations

Natural Sciences, Chemistry, Analytical Chemistry +7

Highly diastereoselective alkylations of chiral amide enolates: new routes to hydroxyethylene dipeptide isostere inhibitors of HIV-1 protease

D. Askin, M A Wallace, Joseph P. Vacca et al. · The Journal of Organic Chemistry · 1992 · 195 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Arenesulfonate derivatives of homochiral glycidol: versatile chiral building blocks for organic synthesis

Janice M. Klunder, Tetsuo Onami, K. Barry Sharpless · The Journal of Organic Chemistry · 1989 · 189 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

1,3-Asymmetric induction: highly stereoselective synthesis of 2,4-trans-disubstituted γ-butyrolactones and γ-butyrothiolactones

Yoshinao Tamaru, Masato Mizutani, Yutaka Furukawa et al. · Journal of the American Chemical Society · 1984 · 128 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors

Terry A. Lyle, Catherine M. Wiscount, James P. Guare et al. · Journal of Medicinal Chemistry · 1991 · 97 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13