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Highly diastereoselective reaction of a chiral, non-racemic amide enolate with (S)-glycidyl tosylate. Synthesis of the orally active HIV-1 protease inhibitor L-735,524

Diastereoselective ReactionMedicinal Chemistry-Glycidyl TosylateBioorganic ChemistryNon-racemic Amide EnolateBiochemistryNatural SciencesMedicineStereoselective SynthesisPharmacologyAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisDrug Discovery