Concepedia

Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

Hongying Yang, Tianle Yang, Joseph A. Baur, Evelyn Perez, Takashi Matsui, Juan J. Carmona, Dudley W. Lamming, Nadja C. de Souza‐Pinto, Vilhelm A. Bohr, Anthony Rosenzweig,

Cell · 2007 · 936 citations · 47 references

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47

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Matt Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development · 1999 · 2.3K citations · Full text

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

Julie St‐Pierre, Stavit Drori, Marc Uldry et al. · Cell · 2006 · 2.2K citations · Full text

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Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin

Atsunori Fukuhara, Morihiro Matsuda, Masako Nishizawa et al. · Science · 2004 · 1.9K citations

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Heidi A. Tissenbaum, Leonard Guarente · Nature · 2001 · 1.9K citations

, , +10