Discovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) Receptor

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTDiscovery of a Novel, Potent, and Orally Active Nonpeptide Antagonist of the Human Luteinizing Hormone-Releasing Hormone (LHRH) ReceptorNobuo Cho, Masataka Harada, Toshihiro Imaeda, Takashi Imada, Hirokazu Matsumoto, Yoji Hayase, Satoshi Sasaki, Shuichi Furuya, Nobuhiro Suzuki, Shoichi Okubo, Kazuhiro Ogi, Satoshi Endo, Haruo Onda, and Masahiko FujinoView Author Information Discovery Research Division, Takeda Chemical Industries, Ltd., 10 Wadai Tsukuba, Ibaraki 300-4293, Japan, and Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 17-85 Jusohonmachi 2-chome Yodogawa-ku, Osaka 532-8686, Japan Cite this: J. Med. Chem. 1998, 41, 22, 4190–4195Publication Date (Web):October 7, 1998Publication History Received17 June 1998Published online7 October 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jm9803673https://doi.org/10.1021/jm9803673rapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views834Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antagonists,Inhibition,Peptides and proteins,Receptors,Rodent models Get e-Alerts