Science · 1971 · 759 citations · 17 references
Life SciencesBiochemistryEndocrinologyNeuroendocrinologyReproductive EndocrinologyReproductive PhysiologyHormone ReleaseHormone SecretionHypothalamic-pituitary RegulationHypothalamic-pituitary-gonadal AxisPeptide Hormone BiochemistryPituitary HormonesFollicle-stimulating Hormone SecretionGonadal Hormone SecretionGonadotropin-releasing Hormone RegulationHypothalamic Hormone SecretionHypothalamic NeurosecretionPituitary Peptide Hormones
A polypeptide isolated from porcine hypothalami stimulates the release of both luteinizing hormone and follicle-stimulating hormone from the pituitaries of several species. This polypeptide has been structurally identified as (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2) and synthesized. The natural and synthetic materials share biological properties. It appears that this peptide represents the hypothalamic hormone regulating the secretion of both luteinizing hormone and follicle-stimulating hormone.
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