Concepedia

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo

Carolyn Algire, Lilian Amrein, Miguel Bazile, Stéphanie David, Mahvash Zakikhani, Michaël Pollak

Oncogene · 2010 · 182 citations · 36 references

DOI

Concepts

References

36

Metformin and reduced risk of cancer in diabetic patients

Josie Evans, Louise A. Donnelly, Alistair Emslie‐Smith et al. · BMJ · 2005 · 2.4K citations · Full text

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy et al. · Proceedings of the National Academy of Sciences · 2004 · 1.8K citations · Full text

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Valeria R. Fantin, Julie St‐Pierre, Philip Leder · Cancer Cell · 2006 · 1.6K citations · Full text

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