Oxidation of Caffeine to Theobromine and Theophylline Is Catalyzed Primarily by Flavin-Containing Monooxygenase in Liver Microsomes

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Medicine, Pharmacology, Toxicology +17

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites

Marguerite A. Butler, Nicholas P. Lang, J.F. Young et al. · Pharmacogenetics · 1992 · 418 citations

Medicine, Biochemistry, Oncology +17

Enzymatic Basis of Detoxication

M. R. TALHA · Biochemical Society Transactions · 1981 · 217 citations

Life Sciences, Biochemistry, Enzymology +7

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene.

Miki Nakajima, Tsuyoshi Yokoi, Mayumi Mizutani et al. · PubMed · 1994 · 142 citations

Medicine, Pharmacology, Toxicology +15