BAG5 Inhibits Parkin and Enhances Dopaminergic Neuron Degeneration

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

Molecular Neuroscience, Mendelian Disorder, Genetic Disorder +7

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

Neil Bence, Roopal M. Sampat, Ron R. Kopito · Science · 2001 · 2.2K citations

Mitophagy, Proteasome, Molecular Biology +19

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Hideki Shimura, Nobutaka Hattori, Shinichiro Kubo et al. · Nature Genetics · 2000 · 2K citations

Ubiquitin-protein Ligase, Mendelian Disorder, Genetics +5

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

Patrick J. Paddison, Amy A. Caudy, Emily Bernstein et al. · Genes & Development · 2002 · 1.5K citations · Full text

Chaperone Suppression of α-Synuclein Toxicity in a <i>Drosophila</i> Model for Parkinson's Disease

Pavan K. Auluck, Ho Yin Edwin Chan, John Q. Trojanowski et al. · Science · 2002 · 1.2K citations

Drosophila Melanogaster, Neurodegenerative Diseases, Mitophagy +14